WORLDWIDE’S EXPERIENCED, AWARD-WINNING STAFF BREEDS EXPERTISE FOR DRUG INTERACTION STUDIES
Anyone who is taking more than one drug is at risk of drug-drug interaction, an issue that occurs when drugs interfere with each other1. Drug-drug interactions can lead to potential issues with efficacy and/or toxicity and have been known to halt drug development. This is where Worldwide can help. Our experience conducting analysis for drug-drug interaction studies spans 3 decades.
Many of our scientists, analysts, and staff have more than 20 years of experience, enabling them to offer the best drug-drug interaction study design support. In addition, our history has enabled us to develop, validate, and utilize assays for the most common drugs assessed during drug-drug interaction studies. We can provide quick reliable results critical to determining your drug’s future.
PHARMACOGENOMICS: A CRITICAL COMPONENT TO YOUR DRUG DEVELOPMENT PROGRAM
Pharmacogenomics is another area which has the potential to impact the drug development process. An individual’s genetic make-up can interfere with the way they respond to or metabolize a drug. For example, some individuals may be poor metabolizers; while others may be rapid metabolizers. This can lead to potential issues with efficacy and/or toxicity. Worldwide knows this information can be critical to your development program.
WORLDWIDE CLINICAL TRIALS: SUPPORTING YOUR PATIENT POPULATION REQUIREMENTS
Worldwide has qualified assays to test for the most common genotypes. A substantial portion of our subject database has been voluntarily screened, saving you time and costs when recruiting special populations. A simple buccal swab is all that is needed to screen for a wide array of genotypes. Our current panel consists of the following and is continually growing.
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Additionally, Worldwide uses validated Agena PGx assays. Based on the results, we can predict phenotypic expression and enzyme activity. Our pharmacogenomics laboratory equipment includes:
- KingFisher Flex magnetic particle processor for DNA extraction
- 2 Thermo ProFlex thermal cyclers for PCR amplification
- Tecan Genesis 200 liquid handler
- Agena MassARRAY Analyzer 4 with Chip Prep Module for MALDI-TOF molecular weight determination of the amplicons
CONTACT AN EXPERT ABOUT YOUR DRUG INTERACTION STUDY